Update on gingival overgrowth by cyclosporine A in renal transplants.
نویسندگان
چکیده
Severe gingival overgrowth is one of the most frequent side effects in renal transplant patients associated with assumption of cyclosporine A. Several associations with age, sex, dosage, duration of therapy or interval since transplantation have been hypothesized. The introduction of alternative immunosuppressant drugs have been suggested to permit better long-term transplant outcomes and a decrease in incidence of gingival overgrowth. The aim of the present paper is to summarize current knowledge regarding aetiology, pathogenesis and management of gingival overgrowth induced by Cyclosporine A.
منابع مشابه
بررسی تأثیر آزیترومایسین در درمان افزایش حجم لثه ناشی از مصرف سیکلوسپورین در بیماران پیوند کلیه
Statement of Problem: Gingival overgrowth is a side effect commonly induced by Cyclosporin treatment. The effects of Azithromycin, a macrolidic antibiotic, has been focused on gingival enlargement treatment induced by cyclosporine in numerous articles. Purpose: The goal of the present study was to survey the effects of systemic Azithromycin in the treatment of gingival overgrowth induced by cyc...
متن کاملCyclosporine-A Induced Gingival Overgrowth
Background. The link between the gingival overgrowth and cyclosporine pharmacokinetical variables, especially cyclosporine doses which appear to act as stimulator of the gingival proliferative changes, presents a field of interest of large number of researches. The existence of undefined association and/or interaction between the cyclosporine and periodontal variables, could be responsible for ...
متن کاملThe effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients.
PURPOSE This investigation was performed to evaluate the effect of cyclosporine alone and in combination with nifedipine on gingival overgrowth. METHODS One hundred and nineteen patients who had undergone renal transplantation at least 12 months previously were selected for the study. The patients were divided into 2 groups according to whether they had received cyclosporine alone (group 1, n...
متن کاملMechanism of azithromycin treatment on gingival overgrowth.
Azithromycin is effective for the remission of cyclosporine A-induced gingival overgrowth (CIGO) in persons who have undergone renal transplant. To explain its mechanism in alleviating the clinical symptoms of these individuals, we examined the effect of azithromycin on cell proliferation and collagen turnover modified by cyclosporin A in human gingival fibroblasts from healthy persons and from...
متن کاملGingival Overgrowth Induced by Immunosuppressive Treatment with Cyclosporine a and Mycophenolate Mofetil in a Patient with Kidney Transplant – a Case Report and Literature Review
Cyclosporine A, a drug that inhibits the immune response, has been widely used for over 30 years in immu‐ nosuppressive therapy protocols for patient‐recipients of the transplanted organs. One of the commonly reported side effects of Cyclosporine A is gingival overgrowth, with varying degrees of severity, which may interfere with the aesthetics and normal functions of the oral cavity. Combi‐ na...
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عنوان ژورنال:
- Medicina oral, patologia oral y cirugia bucal
دوره 12 1 شماره
صفحات -
تاریخ انتشار 2007